Revel M, Schattner A
Department of Virology, Weizmann Institute of Science, Rehovot, Israel.
Ciba Found Symp. 1987;129:223-33. doi: 10.1002/9780470513484.ch15.
The presence of circulating interferons in the blood of patients with autoimmune diseases and the acquired immune deficiency syndrome (AIDS) raises the question of their possible pathogenetic or defence functions. Interferons control levels of HLA class I and II antigens on cells and can activate or inhibit immune killer cell activities. Tumour necrosis factors (TNF) and interleukin 1 induce a new autocrine species of interferon known as IFN-beta-2 whose gene has been cloned, sequenced and expressed. This IFN mediates the increase in HLA expression caused by TNF as well as the antiviral activity of this cytotoxin.
自身免疫性疾病和获得性免疫缺陷综合征（艾滋病）患者血液中循环干扰素的存在，引发了关于其可能的致病或防御功能的问题。干扰素可控制细胞上HLA I类和II类抗原的水平，并能激活或抑制免疫杀伤细胞的活性。肿瘤坏死因子（TNF）和白细胞介素1可诱导一种新的自分泌型干扰素，即IFN-β-2，其基因已被克隆、测序并表达。这种干扰素介导了由TNF引起的HLA表达增加以及这种细胞毒素的抗病毒活性。
