Marcu Loredana G
School of Chemistry and Physics, University of Adelaide, Adelaide, SA 5000, Australia ; Faculty of Science, University of Oradea, 410087 Oradea, Romania.
Biomed Res Int. 2013;2013:817279. doi: 10.1155/2013/817279. Epub 2013 Dec 19.
Advanced head and neck cancers are difficult to manage despite the large treatment arsenal currently available. The multidisciplinary effort to increase disease-free survival and diminish normal tissue toxicity was rewarded with better locoregional control and sometimes fewer side effects. Nevertheless, locoregional recurrence is still one of the main reasons for treatment failure. Today, the standard of care in head and neck cancer management is represented by altered fractionation radiotherapy combined with platinum-based chemotherapy. Targeted therapies as well as chronotherapy were trialled with more or less success. The aim of the current work is to review the available techniques, which could contribute towards a higher therapeutic ratio in the treatment of advanced head and neck cancer patients.
尽管目前有大量的治疗手段,但晚期头颈癌仍难以治疗。为提高无病生存率和减少正常组织毒性而进行的多学科努力,带来了更好的局部区域控制,且有时副作用更少。然而,局部区域复发仍然是治疗失败的主要原因之一。如今,改变分割放疗联合铂类化疗是头颈癌治疗的标准护理方式。靶向治疗以及时间治疗法都进行了试验,或多或少取得了一些成功。当前这项工作的目的是回顾现有的技术,这些技术有助于在晚期头颈癌患者的治疗中提高治疗增益比。