头颈部癌症患者采用顺铂、5-氟尿嘧啶、亚叶酸钙和紫杉醇进行诱导治疗。
Induction Therapy With Cisplatin, 5-Fluorouracil, Leucovorin, and Paclitaxel in Patients With Head and Neck Cancer.
机构信息
Oncology Department, Oncocenter, Teresina, PI, Brazil.
Oncology Department, ABC School of Medicine, Santo André, SP, Brazil.
出版信息
In Vivo. 2023 May-Jun;37(3):1339-1345. doi: 10.21873/invivo.13215.
BACKGROUND/AIM: This study aimed to evaluate the toxicities and response rate of a modified TPF (docetaxel, cisplatin, and 5-fluorouracil) protocol in patients with locally advanced head and neck cancer (ECOG performance status ≤1).
PATIENTS AND METHODS
Induction treatment consisted of cisplatin 25 mg/m/day as a 90 min infusion for three consecutive days, leucovorin 20 mg/m/day as a bolus for four consecutive days, 5-fluorouracil (5-FU) 370 mg/m/day as a bolus for four consecutive days, and paclitaxel 60 mg/m as a 1-h infusion on Days 1, 8, and 15, repeated every 3-4 weeks (twelve cycles to 6 patients).
RESULTS
The main toxicities were grade 1 neuropathy, mucositis, and fatigue. There were four episodes of severe toxicities (grade ≥3). There was one early death, and 2 patients were discontinued due to hematological toxicity. Other side effects included neutropenia, nausea, diarrhea, and vomiting.
CONCLUSION
Induction therapy with cisplatin, 5-fluorouracil, leucovorin, and paclitaxel in head and neck cancer is not feasible because of severe toxicity.
背景/目的：本研究旨在评估改良 TPF（多西紫杉醇、顺铂和 5-氟尿嘧啶）方案在 ECOG 体能状态≤1 的局部晚期头颈部癌症患者中的毒性和缓解率。
患者和方法
诱导治疗包括顺铂 25 mg/m/天，连续 3 天输注 90 分钟，亚叶酸钙 20 mg/m/天，连续 4 天推注，5-氟尿嘧啶（5-FU）370 mg/m/天，连续 4 天推注，紫杉醇 60 mg/m 于第 1、8 和 15 天输注 1 小时，每 3-4 周重复（6 例患者共 12 个周期）。
结果
主要毒性为 1 级神经病变、黏膜炎和疲劳。有 4 例严重毒性（≥3 级）。有 1 例早期死亡，2 例因血液学毒性而停药。其他副作用包括中性粒细胞减少症、恶心、腹泻和呕吐。
结论
顺铂、5-氟尿嘧啶、亚叶酸钙和紫杉醇联合诱导治疗头颈部癌症因毒性严重而不可行。
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