茶碱对人体心房组织的致心律失常作用。

Arrhythmogenic effects of theophylline in human atrial tissue.

作者信息

Lin C I, Chuang I N, Cheng K K, Chiang B N

机构信息

Department of Pharmacology, National Defense Medical Center, Taiwan, Republic of China.

出版信息

Int J Cardiol. 1987 Dec;17(3):289-97. doi: 10.1016/0167-5273(87)90079-9.

DOI:10.1016/0167-5273(87)90079-9

PMID:2445704

Abstract

We studied the effects of theophylline on the transmembrane action potential and the contractile force of human atrial fibers obtained from the hearts of 15 patients, undergoing corrective open-heart surgery. Atrial fibers were perfused with Tyrode solution and driven electrically at a constant rate of 60 beats per min. Theophylline (0.1-1 mM) steepened the diastolic depolarization, increased the amplitude of oscillatory potential during diastole and facilitated the development of spontaneous slow response action potentials. These arrhythmogenic effects of theophylline were suppressed after diltiazem (0.1-0.3 microM) pretreatment. The present findings provide the electrophysiologic evidence that abnormal atrial automaticity as a result of triggered activity may be the underlying cause for atrial ectopic activity and multifocal atrial tachycardia in patients taking theophylline.

摘要

我们研究了茶碱对取自15例接受心脏直视矫正手术患者心脏的人心房纤维跨膜动作电位和收缩力的影响。心房纤维用台氏液灌注，并以每分钟60次的恒定速率进行电驱动。茶碱（0.1 - 1 mM）使舒张期去极化加剧，增加舒张期振荡电位的幅度，并促进自发性缓慢反应动作电位的产生。地尔硫䓬（0.1 - 0.3 microM）预处理后，茶碱的这些致心律失常作用受到抑制。本研究结果提供了电生理学证据，表明因触发活动导致的异常心房自律性可能是服用茶碱患者心房异位活动和多源性房性心动过速的潜在原因。