支气管类癌的预后因素和结果：单中心经验。
Outcome and prognostic factors in bronchial carcinoids: a single-center experience.
机构信息
Departments of *Thoracic Surgery, †Oncology and Biomedical Sciences, University of Torino, Torino, Italy.
出版信息
J Thorac Oncol. 2013 Oct;8(10):1282-8. doi: 10.1097/JTO.0b013e31829f097a.
INTRODUCTION
The aim of this study is to assess factors influencing survival in patients with bronchial carcinoids (BCs).
METHODS
A retrospective review of our surgical database of patients operated for primary lung cancer with a final histologic diagnosis of BC in the period from January 1, 1995 to December 31, 2010 was carried out.
RESULTS
There were 126 patients (74 women): 83 had a typical carcinoid and 43 an atypical one (AC). All patients received a radical resection; systematic lymphadenectomy was accomplished in 120. Lymph nodal metastases were observed in 26 cases (12 N2) and were more frequent in ACs (p = 0.009). Twelve patients received adjuvant therapy (chemo/radio/biological). Distant metastases (DM) and local tumor recurrence occurred in 28 (22%) and 8 (6.3%) cases, respectively: DM were more frequent in ACs (p = 0.0001) and in N2 patients (p = 0.0001). Smoke, atypical histology, lymph nodal metastases, and high cellular proliferative index demonstrated to be statistically negative prognostic factors.
CONCLUSION
Even if characterized by an indolent behavior, BCs may spread to lymph node or distant or present with local recurrence. Amid all prognostic factors, the presence of DM demonstrated to be the strongest negative one.
简介
本研究旨在评估影响支气管类癌（BC）患者生存的因素。
方法
对 1995 年 1 月 1 日至 2010 年 12 月 31 日期间，因原发性肺癌在我院接受手术治疗且最终组织学诊断为 BC 的患者的外科数据库进行回顾性分析。
结果
共纳入 126 例患者（74 例女性）：83 例为典型类癌，43 例为非典型类癌（AC）。所有患者均接受根治性切除术；120 例患者行系统性淋巴结清扫术。26 例（12 例 N2）发生淋巴结转移，AC 中更为常见（p = 0.009）。12 例患者接受辅助治疗（化疗/放疗/生物治疗）。28 例（22%）患者发生远处转移（DM），8 例（6.3%）患者发生局部肿瘤复发：AC 患者中 DM 更为常见（p = 0.0001），N2 患者中 DM 更为常见（p = 0.0001）。吸烟、非典型组织学、淋巴结转移和高细胞增殖指数被证明是统计学上的负预后因素。
结论
即使 BC 表现为惰性行为，也可能发生淋巴结转移、远处转移或局部复发。在所有预后因素中，DM 的存在是最强的负预后因素。
Zotero 插件