Walterscheid Jeffrey P, Phillips Garrett T, Lopez Ana E, Gonsoulin Morna L, Chen Hsin-Hung, Sanchez Luis A
From the Harris County Institute of Forensic Sciences, Houston, TX.
Am J Forensic Med Pathol. 2014 Mar;35(1):20-5. doi: 10.1097/PAF.0000000000000082.
The research compound 25I-NBOMe, also known as CIMBI-5 or INBMeO, was created in academic laboratories as a potent serotonin 2A receptor agonist. Because of its high affinity and ambiguous legal status, recreational drug enthusiasts have used this compound as a powerful alternative to other hallucinogenic drugs such as lysergic acid diethylamide. We report 2 deaths after 25I-NBOMe ingestion by decedents who attended separate "rave" parties. The first case involved a 21-year-old male who admitted taking "acid" to his friend. A sudden violent rage caused him to flail about, and he subsequently became unresponsive. The postmortem examination revealed numerous external injuries that were consistent with physical aggression. The second case involved a 15-year-old female who was socializing outside a rave party, became ill, and rapidly deteriorated as her friend transported her to the hospital. The postmortem assessment was similar to the first case in that external contusions featured prominently. Comprehensive toxicology screens in both cases revealed only evidence of marijuana use. A deeper analysis using time-of-flight mass spectrometry revealed the presence of 25I-NBOMe, which was further confirmed by tandem-mass spectrometry. The behavior and injuries in these cases reveal a consistent pattern preceding fatal 25I-NBOMe toxicity.
研究化合物25I-NBOMe，也被称为CIMBI-5或INBMeO，是在学术实验室中作为一种强效血清素2A受体激动剂合成的。由于其高亲和力和模糊的法律地位，娱乐性药物爱好者将这种化合物用作麦角酸二乙酰胺等其他致幻药物的有力替代品。我们报告了2名分别参加不同“锐舞”派对的死者在摄入25I-NBOMe后死亡的案例。第一例涉及一名21岁男性，他向朋友承认服用了“迷幻剂”。突然发作的暴力狂怒使他胡乱挥舞，随后失去意识。尸检发现多处外部损伤，与身体攻击行为相符。第二例涉及一名15岁女性，她在锐舞派对外社交时生病，在朋友送她去医院的途中病情迅速恶化。尸检评估与第一例相似，外部挫伤较为明显。两例的综合毒理学筛查仅显示有使用大麻的证据。使用飞行时间质谱进行的更深入分析显示存在25I-NBOMe，串联质谱进一步证实了这一点。这些案例中的行为和损伤揭示了25I-NBOMe致命毒性之前的一致模式。
