From the Departments of Surgery, University of Michigan, Ann Arbor, Michigan.
J Trauma Acute Care Surg. 2014 Feb;76(2):469-73. doi: 10.1097/TA.0b013e3182ab0d27.
The oxygenation index (mean airway pressure × FIO2 divided by PaO2) was originally devised to measure severity of illness and predict outcome in neonatal respiratory failure. We evaluated the discrimination of a modified oxygenation index (modified with age) for predicting 28-day mortality in adults with respiratory failure (adult respiratory distress syndrome [ARDS]) using the ALVEOLI section of the ARDSNet database and validated the results in the full ARDSNet database.
We compared age-adjusted oxygenation index (AOI) on ventilator Days 1 to 4 with 28-day mortality.
AOI correlated positively with mortality (area under the receiver operating characteristic curve, 0.70-0.74, for ARDS Days 1-4). Following initial development, AOI related to mortality was validated in two other ARDSNet databases producing similar results (area under the receiver operating characteristic curve, 0.70-0.78).
The observed sensitivity and specificity analysis demonstrated that AOI is equivalent to or better than other mortality prediction systems used for ARDS.
Prognostic, level III.
氧合指数（平均气道压力×吸氧浓度除以动脉血氧分压）最初是为了衡量新生儿呼吸衰竭的严重程度和预测预后而设计的。我们使用 ARDSNet 数据库的 ALVEOLI 部分评估了改良氧合指数（按年龄修正）对成人呼吸衰竭（成人呼吸窘迫综合征 [ARDS]）患者 28 天死亡率的预测能力，并在完整的 ARDSNet 数据库中验证了结果。
我们比较了呼吸机第 1 天至第 4 天的年龄调整氧合指数（AOI）与 28 天死亡率。
AOI 与死亡率呈正相关（ARDS 第 1-4 天的受试者工作特征曲线下面积为 0.70-0.74）。在最初的开发之后，在另外两个 ARDSNet 数据库中验证了与死亡率相关的 AOI，得出了类似的结果（受试者工作特征曲线下面积为 0.70-0.78）。
观察到的敏感性和特异性分析表明，AOI 与用于 ARDS 的其他死亡率预测系统相当或更好。
预后，III 级。
