急性呼吸窘迫综合征中疾病严重程度的生理标志物。
Physiologic Markers of Disease Severity in ARDS.
机构信息
Department of Hospital Medicine, Community Care Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio.
Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio.
出版信息
Respir Care. 2023 Nov 25;68(12):1708-1718. doi: 10.4187/respcare.11100.
Abstract
Despite its significant limitations, the P /F remains the standard tool to classify disease severity in ARDS. Treatment decisions and research enrollment have depended on this parameter for over 50 years. In addition, several variables have been studied over the past few decades, incorporating other physiologic considerations such as ventilation efficiency, lung mechanics, and right-ventricular performance. This review describes the strengths and limitations of all relevant parameters, with the goal of helping us better understand disease severity and possible future treatment targets.
摘要
尽管存在显著的局限性，P/F 仍然是用于分类 ARDS 疾病严重程度的标准工具。超过 50 年来，治疗决策和研究入组都依赖于这一参数。此外，在过去几十年中已经研究了几个变量，纳入了其他生理考虑因素，如通气效率、肺力学和右心室功能。本文描述了所有相关参数的优缺点，目的是帮助我们更好地了解疾病严重程度和可能的未来治疗靶点。
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