From the *Molecular and Imaging Therapy Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York; †Department of Radiology, Weill Cornell Medical Center, New York, NY; ‡Department of Radiology, Memorial Sloan-Kettering Cancer Center, Basking Ridge, NJ; §Division of Hematology/Oncology, Department of Medicine, and ¶Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY.
Clin Nucl Med. 2014 Mar;39(3):288-91. doi: 10.1097/RLU.0000000000000358.
A 70-year-old man with a history of chronic lymphocytic leukemia (CLL) underwent FDG PET/CT scan, which revealed a large polypoid soft tissue lesion in the esophagus with peripheral FDG avidity. An endoscopic biopsy revealed inflammatory changes with scattered CLL cells. The final histopathology demonstrated an 18-cm long and 4-cm wide giant fibrovascular polyp that was removed in 2 pieces. The polyp was composed of atypical adipose tissue with scattered giant cells and spindle-shaped cells as well as foci of CLL. Mouse double minute 2 homolog amplification was noted by fluorescence in situ hybridization diffusely in the giant polyp consistent with well-differentiated liposarcoma in a giant fibrovascular polyp.
一位 70 岁男性，有慢性淋巴细胞白血病（CLL）病史，行 FDG PET/CT 扫描，显示食管内有一个大的息肉样软组织病变，周边 FDG 摄取增加。内镜活检显示炎症改变，伴有散在的 CLL 细胞。最终的组织病理学表现为一个 18cm 长、4cm 宽的巨大纤维血管性息肉，分 2 块切除。息肉由非典型脂肪组织组成，散布有巨细胞和梭形细胞，以及 CLL 病灶。荧光原位杂交显示鼠双微体 2 同源物扩增弥漫性存在于巨大的息肉中，符合巨大纤维血管性息肉中的分化良好的脂肪肉瘤。
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