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Structure of the 2-aminopurine-cytosine base pair formed in the polymerase active site of the RB69 Y567A-DNA polymerase.
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Crystallographic evidence of Watson-Crick connectivity in the base pair of anionic adenine with thymine.
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A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids.
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Dynamic basis for dG•dT misincorporation via tautomerization and ionization.
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Processing of X-ray diffraction data collected in oscillation mode.
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DNA mismatch synthesis complexes provide insights into base selectivity of a B family DNA polymerase.
J Am Chem Soc. 2013 Jan 9;135(1):193-202. doi: 10.1021/ja3079048. Epub 2012 Dec 21.
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Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA.
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Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
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B family DNA polymerases asymmetrically recognize pyrimidines and purines.
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Replication infidelity via a mismatch with Watson-Crick geometry.
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1862-7. doi: 10.1073/pnas.1012825108. Epub 2011 Jan 13.
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Insights into base selectivity from the 1.8 Å resolution structure of an RB69 DNA polymerase ternary complex.
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The kinetic and chemical mechanism of high-fidelity DNA polymerases.
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Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta.
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Coot: model-building tools for molecular graphics.
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