Khan Mohammed A, Pitcher John D, Kawut Steven M, Ho Allen C
Ophthalmic Surg Lasers Imaging Retina. 2014 Mar-Apr;45(2):156-9. doi: 10.3928/23258160-20140124-01. Epub 2014 Jan 23.
Ambrisentan (Letairis; Gilead Sciences, Foster City, CA) is an endothelin receptor antagonist approved by the U.S. Food and Drug Administration for the treatment of pulmonary arterial hypertension. The authors describe the occurrence of bilateral cotton wool spots soon after initiation of ambrisentan treatment in a 29-year-old woman. Fluorescein angiography, optical coherence tomography, and fundus autofluorescence were performed. After discontinuation of ambrisentan, the cotton wool spots resolved without recurrence. To the authors' knowledge, this is the first report of retinopathy in the form of cotton wool spots associated with the use of an endothelin receptor antagonist.
安立生坦（Letairis；吉利德科学公司，加利福尼亚州福斯特城）是一种内皮素受体拮抗剂，已获美国食品药品监督管理局批准用于治疗肺动脉高压。作者描述了一名29岁女性在开始使用安立生坦治疗后不久出现双侧棉絮斑的情况。进行了荧光素血管造影、光学相干断层扫描和眼底自发荧光检查。停用安立生坦后，棉絮斑消退且未复发。据作者所知，这是以棉絮斑形式出现的视网膜病变与使用内皮素受体拮抗剂相关的首例报告。
