Goldenberg D M, Goldenberg H, Higginbotham-Ford E, Shochat D, Ruoslahti E
Center for Molecular Medicine and Immunology, Newark, NJ 07103.
J Clin Oncol. 1987 Nov;5(11):1827-35. doi: 10.1200/JCO.1987.5.11.1827.
Thirteen patients with a history of confirmed liver carcinoma were given either I131 goat polyclonal or murine monoclonal antibodies against alpha-fetoprotein (AFP), and then scanned with a gamma camera. In order to reduce background, nontarget activity, especially in the liver, blood pool, and reticuloendothelial system, 99mTc imaging agents were used for tumor image enhancement by computer-assisted subtraction. A sensitivity of 91% for the primary site, 50% for the lungs (33% for the chest area), and 75% for the abdomen and pelvis was achieved, with a specificity of 100%, 94%, and 100% for these sites, respectively. The accuracy was determined to be 93% for the liver, 86% for the lungs (77% for the chest), and 85% for the abdominal and pelvic area, resulting in an overall accuracy rate for imaging primary and metastatic hepatocellular cancer of 84% (90% if bone metastases are excluded). In two of the 13 patients, lesions that had been missed by conventional liver scintigraphy and transmission computed tomography (CT) were first shown by radioimmunodetection (RAID).
13例确诊为肝癌的患者接受了I131标记的抗甲胎蛋白（AFP）山羊多克隆抗体或鼠单克隆抗体，然后用γ相机进行扫描。为了减少本底、非靶组织活性，特别是肝脏、血池和网状内皮系统的活性，使用99mTc显像剂通过计算机辅助减影来增强肿瘤图像。对原发部位的敏感性为91%，肺部为50%（胸部区域为33%），腹部和骨盆为75%，这些部位的特异性分别为100%、94%和100%。确定肝脏的准确率为93%，肺部为86%（胸部为77%），腹部和骨盆区域为85%，对原发性和转移性肝细胞癌成像的总体准确率为84%（如果排除骨转移则为90%）。在13例患者中的2例中，常规肝脏闪烁扫描和透射计算机断层扫描（CT）漏诊的病变首次通过放射免疫检测（RAID）显示出来。
