Sajjadi S E, Shokoohinia Y, Mehramiri P
Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.
Res Pharm Sci. 2013 Jan;8(1):35-41.
Kelussia odoratissima Mozaff. is an Iranian endangered endemic edible plant with enormous use in the middle region of Iran as food and spice especially yogurt seasoning, and as medicinal herb for anti-inflammatory and cardiovascular purposes. Although antioxidant, anti-inflammatory and antilipidemic effects of this plant have so far been studied, but chemical analyses of the non volatile constituents of the plant have not yet been reported. Therefore, identification of chemical constituents of different parts of plant was investigated in the present study. In this direction, two steroids including stigmasterol and β-sitosterol and one phthalide namely 3-butyliden-4,5-dihydrophthalide were isolated from the plant fruits. In addition, the essential oil composition of the fruits was studied. Thirty eight compounds were identified, of which the major components were found to be Z-ligustilide (29.2%), germacrene-B (15.9%) and germacrene-D (15.5%). According to the previous bioassays of the isolated compounds such as anti-inflammatory and anti-lipidemic effects of phthalides and steroids, a chemical-biological relation can be postulated.
香青兰（Kelussia odoratissima Mozaff.）是一种伊朗濒危的本土可食用植物，在伊朗中部地区作为食物和香料有广泛用途，尤其是用于酸奶调味，还作为具有抗炎和心血管功效的药草。尽管该植物的抗氧化、抗炎和抗血脂作用此前已被研究，但对其非挥发性成分的化学分析尚未见报道。因此，本研究对该植物不同部位的化学成分进行了鉴定。在此过程中，从该植物果实中分离出两种甾体化合物，即豆甾醇和β-谷甾醇，以及一种苯酞类化合物，即3-亚丁基-4,5-二氢苯酞。此外，还对果实的精油成分进行了研究。鉴定出38种化合物，其中主要成分是Z-藁本内酯（29.2%）、杜松烯-B（15.9%）和杜松烯-D（15.5%）。根据之前对分离出的化合物进行的生物测定，如苯酞类化合物和甾体化合物的抗炎和抗血脂作用，可以推测出一种化学-生物学关系。
