McElhiney Linda F
Indiana University Health, Indianapolis, Indiana, USA.
Int J Pharm Compd. 2013 Sep-Oct;17(5):380-3.
Anorectal Crohn's disease is one of the most problematic and debilitating forms of Crohn's disease. Crohn's disease is a type of inflammatory bowel disease that usually affects the intestines but may occur anywhere in the gastrointestinal tract and is frequently refractory to medication, which may ultimately result in proctocolectomy and ileostomy surgeries. It is reported in 3% to 5% of Crohn's patients and is found in conjunction with colorectal or enteric disease in one-third to one-half of Crohn's disease patients. This article discusses the use of metronidazole 10% ointment for the treatment of anorectal Crohn's disease. Since metronidazole is not U.S. Food and Drug Administration approved for treating anorectal Crohn's disease, and there is no commercially available metronidazole 10% ointment, compounding pharmacists can play a role in providing this dosage form. This article discusses some of the common symptoms of Crohn's disease and the use of topical metronidazole to treat the disease.
肛门直肠克罗恩病是克罗恩病中最棘手且使人虚弱的形式之一。克罗恩病是一种炎症性肠病，通常影响肠道，但也可能发生在胃肠道的任何部位，并且常常对药物治疗无效，最终可能导致直肠结肠切除术和回肠造口术。据报道，3%至5%的克罗恩病患者患有肛门直肠克罗恩病，并且在三分之一至二分之一的克罗恩病患者中，它与结直肠或肠道疾病同时存在。本文讨论了10%甲硝唑软膏在治疗肛门直肠克罗恩病中的应用。由于甲硝唑未被美国食品药品监督管理局批准用于治疗肛门直肠克罗恩病，且没有市售的10%甲硝唑软膏，配制药剂师可以在提供这种剂型方面发挥作用。本文讨论了克罗恩病的一些常见症状以及外用甲硝唑治疗该疾病的情况。
