Al Wattar Bassel H, Hillman Sarah C, Marton Tamas, Foster Katharine, Kilby Mark D
Fetal Medicine Centre, Birmingham Women's Foundation Trust , Birmingham , UK .
J Matern Fetal Neonatal Med. 2014 Jul;27(10):1055-63. doi: 10.3109/14767058.2013.847424. Epub 2013 Oct 17.
Placental chorioangioma is a relatively rare condition that often results in serious prenatal complications and adverse pregnancy outcome. We report a case of a large chorioangioma that was prenatally diagnosed at 23 weeks with polyhydramnios and fetal anemia. With prenatal monitoring, transplacental therapy with a COX-2 inhibitor and intrauterine transfusion, the pregnancy resulted in the live birth at 30 weeks. Due to the paucity of evidence relating to the management protocols in cases of placental chorioangiomas, we have conducted a systematic review of the literature.
All reported cases in the English language were captured using the electronic databases. Bibliographies of relevant articles were manually searched.
Sixty-four articles were included reporting 112 cases of placental chorioangioma. In 79, there was no prenatal treatment and in 33 there was in-utero treatment. A systematic comparison of antenatal complications and pregnancy outcomes was performed. No strong conclusion could be made due to the low number and quality of the reported cases.
Placenta chorioangioma represents a challenge with its potentially serious complications adversely affecting pregnancy outcome. An international registry of pregnancies with this rare complication and documentation of pregnancy outcomes will improve the evidence base for prospective management.
胎盘绒毛膜血管瘤是一种相对罕见的病症，常导致严重的产前并发症及不良妊娠结局。我们报告一例大型绒毛膜血管瘤病例，该病例于孕23周时经产前诊断为羊水过多和胎儿贫血。通过产前监测、经胎盘给予环氧化酶-2抑制剂治疗及宫内输血，妊娠于孕30周时分娩出活婴。鉴于关于胎盘绒毛膜血管瘤病例管理方案的证据匮乏，我们对文献进行了系统综述。
利用电子数据库收集所有英文报道的病例。手动检索相关文章的参考文献。
纳入64篇文章，报道了112例胎盘绒毛膜血管瘤病例。其中79例未接受产前治疗，33例接受了宫内治疗。对产前并发症和妊娠结局进行了系统比较。由于报道病例数量少且质量不高，无法得出有力结论。
胎盘绒毛膜血管瘤因其潜在的严重并发症对妊娠结局产生不利影响而构成挑战。建立一个关于这种罕见并发症妊娠的国际登记处并记录妊娠结局，将改善前瞻性管理的证据基础。
