术中钇-90正电子发射断层扫描/计算机断层扫描用于钇-90放射性栓塞治疗的优化
Intraprocedural yttrium-90 positron emission tomography/CT for treatment optimization of yttrium-90 radioembolization.
作者信息
Bourgeois Austin C, Chang Ted T, Bradley Yong C, Acuff Shelley N, Pasciak Alexander S
机构信息
Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920.
Molecular Imaging and Translational Research Program, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920.
出版信息
J Vasc Interv Radiol. 2014 Feb;25(2):271-5. doi: 10.1016/j.jvir.2013.11.004.
Radioembolization with yttrium-90 ((90)Y) microspheres relies on delivery of appropriate treatment activity to ensure patient safety and optimize treatment efficacy. We report a case in which (90)Y positron emission tomography (PET)/computed tomography (CT) was performed to optimize treatment planning during a same-day, three-part treatment session. This treatment consisted of (i) an initial (90)Y infusion with a dosage determined using an empiric treatment planning model, (ii) quantitative (90)Y PET/CT imaging, and (iii) a secondary infusion with treatment planning based on quantitative imaging data with the goal of delivering a specific total tumor absorbed dose.
使用钇-90（90Y）微球进行放射性栓塞依赖于给予适当的治疗活度，以确保患者安全并优化治疗效果。我们报告了一例在同一天分三个步骤进行的治疗过程中，采用90Y正电子发射断层扫描（PET）/计算机断层扫描（CT）来优化治疗计划的病例。该治疗包括：（i）首次输注90Y，使用经验性治疗计划模型确定剂量；（ii）定量90Y PET/CT成像；（iii）基于定量成像数据进行治疗计划的二次输注，目标是给予特定的总肿瘤吸收剂量。
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