Osborne Dustin R, Acuff Shelley N, Neveu Melissa L, Syed Mumtaz, Kaman Austin D, Fu Yitong
Department of Radiology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee, USA.
Nucl Med Commun. 2018 Mar;39(3):222-227. doi: 10.1097/MNM.0000000000000794.
The usage of PET/computed tomography (CT) to monitor hepatocellular carcinoma patients following yttrium-90 (Y) radioembolization has increased. Respiratory motion causes liver movement, which can be corrected using gating techniques at the expense of added noise. This work examines the use of amplitude-based gating on Y-PET/CT and its potential impact on diagnostic integrity.
Patients were imaged using PET/CT following Y radioembolization. A respiratory band was used to collect respiratory cycle data. Patient data were processed as both standard and motion-corrected images. Regions of interest were drawn and compared using three methods. Activity concentrations were calculated and converted into dose estimates using previously determined and published scaling factors. Diagnostic assessments were performed using a binary scale created from published Y-PET/CT image interpretation guidelines.
Estimates of radiation dose were increased (P<0.05) when using amplitude-gating methods with Y PET/CT imaging. Motion-corrected images show increased noise, but the diagnostic determination of success, using the Kao criteria, did not change between static and motion-corrected data.
Amplitude-gated PET/CT following Y radioembolization is feasible and may improve Y dose estimates while maintaining diagnostic assessment integrity.
正电子发射断层扫描/计算机断层扫描（PET/CT）用于监测钇-90（Y）放射性栓塞术后肝细胞癌患者的情况日益增多。呼吸运动会导致肝脏移动，可使用门控技术进行校正，但代价是增加噪声。本研究探讨基于幅度的门控技术在Y-PET/CT中的应用及其对诊断完整性的潜在影响。
患者在接受Y放射性栓塞术后接受PET/CT成像。使用呼吸带收集呼吸周期数据。患者数据被处理为标准图像和运动校正图像。使用三种方法绘制感兴趣区域并进行比较。计算活性浓度，并使用先前确定并公布的比例因子将其转换为剂量估计值。使用根据已发表的Y-PET/CT图像解读指南创建的二元量表进行诊断评估。
在Y PET/CT成像中使用幅度门控方法时，辐射剂量估计值增加（P<0.05）。运动校正图像显示噪声增加，但根据考氏标准，静态数据和运动校正数据之间的诊断成功判定没有变化。
Y放射性栓塞术后进行幅度门控PET/CT是可行的，可能会改善Y剂量估计，同时保持诊断评估的完整性。
