白细胞介素1β（IL1B）（-511）、白细胞介素1β（IL1B）（+3954）、白细胞介素1受体拮抗剂（IL1RN）（可变数目串联重复序列，VNTR）基因多态性与格雷夫斯病风险之间的关联：11项病例对照研究的荟萃分析
Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and Graves' disease risk: a meta-analysis of 11 case-control studies.
作者信息
Chen Min-Li, Liao Ning, Zhao Hua, Huang Jian, Xie Zheng-Fu
机构信息
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Department of Clinical Medicine, Grade 2001, Guangxi Medical University, Nanning, China.
出版信息
PLoS One. 2014 Jan 21;9(1):e86077. doi: 10.1371/journal.pone.0086077. eCollection 2014.
BACKGROUND
Data on the association between the interleukin-1 (IL-1) gene polymorphisms and Graves' disease (GD) risk were conflicting. A meta-analysis was undertaken to assess this association.
METHODS
We searched for case-control studies investigating the association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk. We extracted data using standardized forms and calculated odds ratios (OR) with 95% confidence intervals (CI).
RESULTS
A total of 11 case-control studies were included in this meta-analysis. Available data indicated that the IL1B (-511) polymorphism was associated with GD risk in the overall populations (Caucasians and Asians) in homozygote model (TT vs. CC, OR = 0.86, 95% CI: 0.76-0.97, Pz = 0.015), but not in dominant and recessive models (TT+TC vs. CC: OR = 0.95, 95% CI: 0.81-1.12, Pz = 0.553 and TT vs. TC+CC: OR = 0.82, 95% CI: 0.60-1.12, Pz = 0.205, respectively). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was found in the overall populations in any of the genetic models. In subgroup analyses according to ethnicity, the IL1B (-511) polymorphism was associated with GD risk in Asians in recessive and homozygote models (TT vs. TC+CC: OR = 0.68, 95% CI: 0.55-0.84, Pz < 0.001 and TT vs. CC: OR = 0.81, 95% CI: 0.70-0.93, Pz = 0.003, respectively), but not in dominant model (TT+TC vs. CC: OR = 0.92, 95% CI: 0.77-1.11, Pz = 0.389). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was indicated in Asians, and we found no association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk in Caucasians in any of the genetic models.
CONCLUSION
The IL1B (-511) polymorphism, but not the IL1B (+3954) and IL1RN (VNTR) polymorphisms was associated with GD risk in Asians. There was no association between these polymorphisms and GD risk in Caucasians.
背景
白细胞介素 -1（IL-1）基因多态性与格雷夫斯病（GD）风险之间的关联数据存在冲突。进行了一项荟萃分析以评估这种关联。
方法
我们检索了调查IL1B（-511）、IL1B（+3954）、IL1RN（VNTR）多态性与GD风险之间关联的病例对照研究。我们使用标准化表格提取数据，并计算了比值比（OR）及95%置信区间（CI）。
结果
本荟萃分析共纳入11项病例对照研究。现有数据表明，在纯合子模型中，IL1B（-511）多态性与总体人群（白种人和亚洲人）的GD风险相关（TT与CC相比，OR = 0.86，95%CI：0.76 - 0.97，P = 0.015），但在显性和隐性模型中不相关（TT + TC与CC相比：OR = 0.95，95%CI：0.81 - 1.12，P = 0.553；TT与TC + CC相比：OR = 0.82，95%CI：0.60 - 1.12，P = 0.205）。在任何遗传模型中，总体人群中均未发现IL1B（+3954）、IL1RN（VNTR）多态性与GD风险之间存在关联。在按种族进行的亚组分析中，IL1B（-511）多态性在隐性和纯合子模型中与亚洲人的GD风险相关（TT与TC + CC相比：OR = 0.68，95%CI：0.55 - 0.84，P < 0.001；TT与CC相比：OR = 0.81，95%CI：0.70 - 0.93，P = 0.003），但在显性模型中不相关（TT + TC与CC相比：OR = 0.92，95%CI：0.77 - 1.11，P = 0.389）。亚洲人中未发现IL1B（+3954）、IL1RN（VNTR）多态性与GD风险之间存在关联；在任何遗传模型中，白种人中IL1B（-511）、IL1B（+3954）、IL1RN（VNTR）多态性与GD风险之间均无关联。
结论
IL1B（-511）多态性与亚洲人的GD风险相关，而IL1B（+3954）和IL1RN（VNTR）多态性与亚洲人的GD风险无关。这些多态性与白种人的GD风险之间无关联。
Zotero 插件