Chen Min-Li, Liao Ning, Zhao Hua, Huang Jian, Xie Zheng-Fu
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Department of Clinical Medicine, Grade 2001, Guangxi Medical University, Nanning, China.
PLoS One. 2014 Jan 21;9(1):e86077. doi: 10.1371/journal.pone.0086077. eCollection 2014.
Data on the association between the interleukin-1 (IL-1) gene polymorphisms and Graves' disease (GD) risk were conflicting. A meta-analysis was undertaken to assess this association.
We searched for case-control studies investigating the association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk. We extracted data using standardized forms and calculated odds ratios (OR) with 95% confidence intervals (CI).
A total of 11 case-control studies were included in this meta-analysis. Available data indicated that the IL1B (-511) polymorphism was associated with GD risk in the overall populations (Caucasians and Asians) in homozygote model (TT vs. CC, OR = 0.86, 95% CI: 0.76-0.97, Pz = 0.015), but not in dominant and recessive models (TT+TC vs. CC: OR = 0.95, 95% CI: 0.81-1.12, Pz = 0.553 and TT vs. TC+CC: OR = 0.82, 95% CI: 0.60-1.12, Pz = 0.205, respectively). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was found in the overall populations in any of the genetic models. In subgroup analyses according to ethnicity, the IL1B (-511) polymorphism was associated with GD risk in Asians in recessive and homozygote models (TT vs. TC+CC: OR = 0.68, 95% CI: 0.55-0.84, Pz < 0.001 and TT vs. CC: OR = 0.81, 95% CI: 0.70-0.93, Pz = 0.003, respectively), but not in dominant model (TT+TC vs. CC: OR = 0.92, 95% CI: 0.77-1.11, Pz = 0.389). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was indicated in Asians, and we found no association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk in Caucasians in any of the genetic models.
The IL1B (-511) polymorphism, but not the IL1B (+3954) and IL1RN (VNTR) polymorphisms was associated with GD risk in Asians. There was no association between these polymorphisms and GD risk in Caucasians.
白细胞介素 -1（IL-1）基因多态性与格雷夫斯病（GD）风险之间的关联数据存在冲突。进行了一项荟萃分析以评估这种关联。
我们检索了调查IL1B（-511）、IL1B（+3954）、IL1RN（VNTR）多态性与GD风险之间关联的病例对照研究。我们使用标准化表格提取数据，并计算了比值比（OR）及95%置信区间（CI）。
本荟萃分析共纳入11项病例对照研究。现有数据表明，在纯合子模型中，IL1B（-511）多态性与总体人群（白种人和亚洲人）的GD风险相关（TT与CC相比，OR = 0.86，95%CI：0.76 - 0.97，P = 0.015），但在显性和隐性模型中不相关（TT + TC与CC相比：OR = 0.95，95%CI：0.81 - 1.12，P = 0.553；TT与TC + CC相比：OR = 0.82，95%CI：0.60 - 1.12，P = 0.205）。在任何遗传模型中，总体人群中均未发现IL1B（+3954）、IL1RN（VNTR）多态性与GD风险之间存在关联。在按种族进行的亚组分析中，IL1B（-511）多态性在隐性和纯合子模型中与亚洲人的GD风险相关（TT与TC + CC相比：OR = 0.68，95%CI：0.55 - 0.84，P < 0.001；TT与CC相比：OR = 0.81，95%CI：0.70 - 0.93，P = 0.003），但在显性模型中不相关（TT + TC与CC相比：OR = 0.92，95%CI：0.77 - 1.11，P = 0.389）。亚洲人中未发现IL1B（+3954）、IL1RN（VNTR）多态性与GD风险之间存在关联；在任何遗传模型中，白种人中IL1B（-511）、IL1B（+3954）、IL1RN（VNTR）多态性与GD风险之间均无关联。
IL1B（-511）多态性与亚洲人的GD风险相关，而IL1B（+3954）和IL1RN（VNTR）多态性与亚洲人的GD风险无关。这些多态性与白种人的GD风险之间无关联。
