Bouguermouh D, Salem A
Pediatric Surgery Department, Pr Nefissa Hamoud University Hospital Center, Algiers, Algeria; Faculty of Medical Sciences, University of Algiers, Algiers, Algeria.
Dis Esophagus. 2015 Apr;28(3):205-10. doi: 10.1111/dote.12174. Epub 2014 Jan 28.
The purpose was to study the outcomes and factors affecting the survival of esophageal atresia in our center. A retrospective analysis of 86 cases of esophageal atresia (EA) over a 10-year period was performed with 46 boys and 42 girls. Demographic data, birth weight, gestational age, consanguinity, incidence of associated anomalies, place of delivery, history of feeding, and outcomes were studied. EA with distal tracheoesophageal fistula (TEF) was the commonest type with 58/86 (67%). The percentage of patients with at least one associated anomaly was 52/86 (60%), with 7/86 (8%) who are from consanguineous parents; most commonly associated anomalies were cardiac 13/86 (15%). The average gestational age and birth weight were 36 ± 2 weeks and 2300 ± 570 g, respectively. Survival rates for the patients according to the Waterston classification was 80% in group A, 58% in group B, and 25% in group C (three patients died before surgery). Prematurity, the gap between the two ends of the esophagus, and preoperative respiratory status were the most significant factors affecting the survival. Late complication of EA/TEF include respiratory symptoms, especially in the first year, associating tracheomalacia and bronchopulmonary infections in about 24/45 (53%), recurrence of TEF 3/45 (7%), esophageal stricture 26/45 (58%), and gastroesophageal reflux 22/45 (49%). The high incidence of delayed diagnosis, low birth weight, and lack of advanced neonatological management are important contributory factors to the poor outcome. The frequency of late complications highlights the need for multidisciplinary clinics to follow these children's.
本研究旨在探讨我院食管闭锁患儿的预后情况及影响其生存的因素。对我院10年间收治的86例食管闭锁(EA)患儿进行回顾性分析,其中男46例,女42例。研究内容包括人口统计学资料、出生体重、孕周、近亲结婚情况、合并畸形发生率、分娩地点、喂养史及预后等。食管闭锁合并远端气管食管瘘(TEF)最为常见,共58例(67%)。至少合并一种其他畸形的患儿有52例(60%),其中7例(8%)患儿父母为近亲结婚;最常见的合并畸形为心脏畸形,共13例(15%)。患儿平均孕周和出生体重分别为36±2周和2300±570g。根据Waterston分类,A组患儿生存率为80%,B组为58%,C组为25%(3例患儿术前死亡)。早产、食管两端间距及术前呼吸状况是影响生存的最重要因素。食管闭锁/气管食管瘘的晚期并发症包括呼吸道症状,尤其是在第一年,约24/45例(53%)出现气管软化和支气管肺感染,3/45例(7%)出现气管食管瘘复发,26/45例(58%)出现食管狭窄,22/45例(49%)出现胃食管反流。诊断延误、低出生体重及缺乏先进新生儿管理是导致预后不良的重要因素。晚期并发症的高发生率凸显了多学科门诊随访这些患儿的必要性。