体外经7,12-二甲基苯并[a]蒽处理的小鼠角质形成细胞系中的良性和恶性肿瘤阶段
Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro.
作者信息
Kulesz-Martin M F, Penetrante R, East C J
机构信息
Grace Cancer Drug Center, Roswell Park Memorial Institute, Buffalo, NY 14263.
出版信息
Carcinogenesis. 1988 Jan;9(1):171-4. doi: 10.1093/carcin/9.1.171.
PMID:2446796
Abstract
Stable pre-tumorigenic, benign tumor and squamous cell carcinoma stages have been isolated after treatment of a cloned mouse keratinocyte line with 7,12-dimethylbenz[a]anthracene. Intraperitoneal injection and skin grafting of athymic nude mice were suitable for growth of these well-differentiated tumor cells, whereas subcutaneous injection was not.
摘要
在用7,12-二甲基苯并[a]蒽处理克隆的小鼠角质形成细胞系后，已分离出稳定的肿瘤前、良性肿瘤和鳞状细胞癌阶段。无胸腺裸鼠的腹腔注射和皮肤移植适合这些高度分化的肿瘤细胞生长，而皮下注射则不适合。
Zotero 插件