Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
Int J Surg. 2014;12(4):346-52. doi: 10.1016/j.ijsu.2014.01.010. Epub 2014 Jan 25.
The aim of this study was to evaluate the impact of obesity on surgical outcome and prognosis in patients with gastric cancer.
A total of 304 patients who underwent curative gastrectomy for gastric adenocarcinoma between January 2005 and March 2008were enrolled. Body mass index (BMI) was calculated before the operation and visceral fat area (VFA) was measured by abdominal computed tomography (CT). The patients were divided according to BMI class and VFA quartile. The influence of BMI and VFA on surgical outcome and survival was evaluated.
The median BMI was 23.3 kg/m(2) and the median VFA was 103 cm(2). There was a significant positive correlation between BMI and VFA. According to BMI class and VFA quartile, there were no significant differences in patients' characteristics or surgical outcome, with the exception of a significantly longer operation time and fewer retrieved lymph nodes in patients with a high BMI and VFA. The unadjusted overall and disease free survival were not significantly different between BMI classes or VFA quartiles.
Obesity, as represented by BMI and VFA, may not be a poor prognostic factor in patients with gastric cancer.
本研究旨在评估肥胖对胃癌患者手术结果和预后的影响。
本研究纳入了 2005 年 1 月至 2008 年 3 月期间接受胃腺癌根治性胃切除术的 304 例患者。手术前计算体重指数（BMI），通过腹部 CT 测量内脏脂肪面积（VFA）。根据 BMI 分级和 VFA 四分位将患者进行分组。评估 BMI 和 VFA 对手术结果和生存的影响。
BMI 的中位数为 23.3kg/m²，VFA 的中位数为 103cm²。BMI 与 VFA 之间存在显著正相关。根据 BMI 分级和 VFA 四分位，患者的特征或手术结果没有显著差异，但高 BMI 和 VFA 的患者手术时间明显延长，淋巴结检出数明显减少。未调整的总生存率和无病生存率在 BMI 分级或 VFA 四分位之间无显著差异。
肥胖（以 BMI 和 VFA 表示）可能不是胃癌患者的预后不良因素。
