Deblois D, Marceau F
Unité de Recherche sur l'Inflammation et en Immunologie et Rhumatologie, Centre Hospitalier de L'Université Laval, Québec, Canada.
Eur J Pharmacol. 1987 Oct 6;142(1):141-4. doi: 10.1016/0014-2999(87)90664-9.
Strips of rabbit mesenteric arteries precontracted with phenylephrine relaxed when exposed to des-Arg9-bradykinin (BK), a typical B1 receptor agonist. We showed that the ability of des-Arg9-BK to relax this preparation was acquired during in vitro incubation and was abolished by cycloheximide treatment. In this preparation intimal damage reduced but did not abolish the relaxant effect of des-Arg9-BK, and indomethacin uncovered a contractile effect of des-Arg9-BK also acquired during the in vitro incubation.
预先用去氧肾上腺素预收缩的兔肠系膜动脉条，在暴露于去精氨酸9-缓激肽（BK，一种典型的B1受体激动剂）时会舒张。我们发现，去精氨酸9-缓激肽舒张这种标本的能力是在体外孵育过程中获得的，并且会被环己酰亚胺处理所消除。在这个标本中，内膜损伤会降低但不会消除去精氨酸9-缓激肽的舒张作用，并且吲哚美辛揭示了去精氨酸9-缓激肽的收缩作用也是在体外孵育过程中获得的。
