Zalewski Przemysław, Skibiński Robert, Cielecka-Piontek Judyta
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.
Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
J Pharm Biomed Anal. 2014 Apr;92:22-5. doi: 10.1016/j.jpba.2013.12.039. Epub 2014 Jan 7.
The process of degradation was studied by using an HPLC-DAD method. Four degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The influence of temperature and relative air humidity (RH) on the stability of cefpirome sulfate was investigated. In the solid state the degradation of cefpirome sulfate was a first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of degradation were calculated.
采用高效液相色谱-二极管阵列检测法（HPLC-DAD）研究了降解过程。使用混合电喷雾电离-四极杆-飞行时间质谱仪（ESI-Q-TOF）鉴定出四种降解产物。考察了温度和相对空气湿度（RH）对硫酸头孢匹罗稳定性的影响。在固态下，硫酸头孢匹罗的降解是取决于底物浓度的一级反应。计算了降解的动力学和热力学参数。
