曲克芦丁治疗后闭塞性动脉硬化症患者的一些血液流变学因素
Some haemorheological factors in patients with arteriosclerosis obliterans after treatment of trental.
作者信息
Chyzy R, Lukjan H, Rość D, Bielawiec M, Sawicka J
机构信息
Department of Basic Medical Care, Medical School Bialystok, Poland.
出版信息
Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(4):549-54.
Erythrocytes deformability, plasma cAMP, 6-keto-PGF1 alpha, TXB2 levels and fibrinolytic activity in patients suffering from arteriosclerosis obliterans before and after Trental were studied. Trental improved the deformability of red cells and resulted in an enhancement of diminished cAMP level in plasma and increased the fibrinolytic activity. The improvement of deformability observed after Trental could depend upon the influence of a higher cAMP level in plasma on the erythrocyte membrane. The increase of cAMP level seems to be the result of the inhibiting effect of Trental on phosphodiesterase and of higher fibrinolytic activity.
研究了患有闭塞性动脉硬化症的患者在服用曲克芦丁前后红细胞变形性、血浆环磷酸腺苷（cAMP）、6-酮-前列腺素F1α、血栓素B2水平及纤溶活性。曲克芦丁改善了红细胞的变形性，使血浆中降低的cAMP水平升高，并提高了纤溶活性。服用曲克芦丁后观察到的变形性改善可能取决于血浆中较高的cAMP水平对红细胞膜的影响。cAMP水平的升高似乎是曲克芦丁对磷酸二酯酶的抑制作用及较高纤溶活性的结果。
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