Lukjan H, Rość D, Chyzy R, Bodzenta A, Szpak A
Folia Haematol Int Mag Klin Morphol Blutforsch. 1985;112(1):191-6.
Deformability of red cells and plasma levels of cAMP and cGMP were studied in patients with arteriosclerosis obliterans of lower limbs. Deformability of red cells and plasma levels of cAMP were found to be decreased in these patients. Venous injection of HR (Venoruton) in one dose (1,000 mg) to patients, led to an increase of red cell deformability and normalisation of cAMP plasma level. The plasma level of cGMP was not changed. The beneficial effect of HR in arteriosclerosis obliterans depends, first of all, on improving the deformability of red cells. The decreased deformability observed in arteriosclerosis seems to be a result of disturbances in the rate of spectrin phosphorylation of the erythrocyte membrane. By normalising the plasma level of cAMP HR had a considerable influence on the appropriate state of elasticity of the red cell membrane.
对下肢闭塞性动脉硬化患者的红细胞变形能力以及血浆中cAMP和cGMP水平进行了研究。发现这些患者的红细胞变形能力和血浆cAMP水平降低。对患者静脉注射一剂（1000毫克）HR（维脑路通）后，红细胞变形能力增加，血浆cAMP水平恢复正常。血浆cGMP水平未发生变化。HR对闭塞性动脉硬化的有益作用首先取决于改善红细胞的变形能力。在动脉硬化中观察到的变形能力下降似乎是红细胞膜血影蛋白磷酸化速率紊乱的结果。通过使血浆cAMP水平恢复正常，HR对红细胞膜的适当弹性状态产生了相当大的影响。
