铜催化的烯烃与羟胺的区域和对映选择性氢胺化反应。
Copper-catalyzed regio- and enantioselective hydroamination of alkenes with hydroxylamines.
机构信息
Worldwide Medicinal Chemistry, Pfizer, Inc. Eastern Point Rd., Groton, CT 06340 (USA).
出版信息
Angew Chem Int Ed Engl. 2014 Feb 17;53(8):2034-6. doi: 10.1002/anie.201309262. Epub 2014 Jan 27.
PMID:24470434
Abstract
Adding value: The catalytic hydroamination of alkenes with amines holds promise to rapidly deliver value-added chiral amines from simple and accessible starting materials. The use of mild, Cu-catalyzed electrophilic amination strategies for the regioselective preparation of both linear and chiral branched amines is highlighted.
摘要
增值
烯烃与胺的催化氢胺化有望从简单易得的起始原料快速合成具有附加值的手性胺。本文重点介绍了温和的、铜催化的亲电胺化策略在区域选择性制备线性和手性支链胺中的应用。
Zotero 插件