Gorgas Stephen, Abuhammour Walid, Blackwood R Alexander
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School , Ann Arbor, MI.
Department of Pediatrics, Hurley Medical Center, Flint, MI, USA.
Infect Dis Rep. 2013 Jun 3;5(1):e6. doi: 10.4081/idr.2013.e6. eCollection 2013 Jan 22.
We present a case of hyperimmunoglobulin E (hyper-IgE) syndrome in a three year old boy. There are many pitfalls in diagnosing this disease in the very young population, mainly due to the ambiguity of some diagnostic criteria in this population. Recognizing this syndrome early in life can potentially be very beneficial to the patients involved and the medical system as a whole. Early diagnosis can lead to fewer diagnostic tests, fewer referrals, and more focused exams, thus potentially reducing medical cost while also reducing the number of serious infections later in life, including those which are potentially fatal. Additionally, a wellknown association between lymphoma and hyper-IgE syndrome has been established; while no recommendations are currently in place for screening, early diagnosis could help medical providers have a higher threshold for diagnosis of this disease.
我们报告一例3岁男孩的高免疫球蛋白E（高IgE）综合征病例。在非常年幼的人群中诊断这种疾病存在许多陷阱，主要是因为该人群中一些诊断标准不明确。在生命早期识别这种综合征对相关患者和整个医疗系统可能非常有益。早期诊断可以减少诊断测试、转诊次数，并使检查更具针对性，从而有可能降低医疗成本，同时还能减少日后生活中严重感染的数量，包括那些可能致命的感染。此外，淋巴瘤与高IgE综合征之间已建立起一种众所周知的关联；虽然目前尚无筛查建议，但早期诊断有助于医疗人员提高对该疾病的诊断阈值。
