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一种可逆转的肺动脉束带:初步经验

A reversible pulmonary artery band: preliminary experience.

作者信息

Rocchini A P, Gundry S R, Beekman R H, Gallagher K P, Heidelberger K, Bove E, Behrendt D M, Dysko R C, Rosen K

机构信息

Department of Pediatrics, University of Michigan, Medical Center, Ann Arbor 48109-0204.

出版信息

J Am Coll Cardiol. 1988 Jan;11(1):172-6. doi: 10.1016/0735-1097(88)90185-4.

Abstract

Pulmonary artery banding has become an infrequently used surgical technique. However, if a band was developed that could be relieved without the need for open heart surgery, it is likely that pulmonary artery banding would be used more frequently in the management of infants with congenital heart disease. Such a pulmonary artery band was placed in seven 1 week old mongrel puppies by using a loop of an absorbable suture material (Vicryl). One dog died at 2 months as a result of right ventricular failure. The remaining six dogs underwent cardiac catheterization and pulmonary balloon angioplasty at 6 months of age. After measuring pulmonary artery, right ventricular and aortic pressures and performing a right ventricular angiogram, balloon angioplasty of the band site was performed. A 20 mm balloon angioplasty catheter (Medi-Tech) was used in all dogs. Balloon angioplasty decreased right ventricular pressure from 101 +/- 19 to 42 +/- 3 mm Hg (p less than 0.05) and right ventricular systolic outflow tract gradient from 59 +/- 14 to 7 +/- 2 mm Hg (p less than 0.03), and increased the size of the band site from 8.7 +/- 0.03 to 14.9 +/- 0.5 mm (p less than 0.01). All dogs were recatheterized 2 months after angioplasty and were then killed for pathologic evaluation. At follow-up catheterization, right ventricular pressure, right ventricular outflow tract gradient and pulmonary artery size at the band site remained at the values obtained immediately after angioplasty. Postmortem examination demonstrated that there was no evidence of pulmonary artery damage. Although these studies are preliminary, they suggest that a reversible pulmonary artery band can be performed.

摘要

肺动脉环扎术已成为一种较少使用的外科技术。然而,如果能研发出一种无需开胸手术就能解除的环扎带,那么肺动脉环扎术在先天性心脏病婴儿的治疗中可能会更频繁地被使用。使用可吸收缝合材料(薇乔)的线圈,在7只1周龄的杂种幼犬中放置了这样一种肺动脉环扎带。1只狗在2个月时因右心室衰竭死亡。其余6只狗在6个月大时接受了心导管检查和肺动脉球囊血管成形术。在测量肺动脉、右心室和主动脉压力并进行右心室血管造影后,对环扎部位进行了球囊血管成形术。所有狗均使用20毫米球囊血管成形术导管(美敦力)。球囊血管成形术使右心室压力从101±19毫米汞柱降至42±3毫米汞柱(p<0.05),右心室收缩期流出道梯度从59±14毫米汞柱降至7±2毫米汞柱(p<0.03),并使环扎部位的大小从8.7±0.03毫米增加到14.9±0.5毫米(p<0.01)。所有狗在血管成形术后2个月再次进行导管检查,然后处死进行病理评估。在随访导管检查时,右心室压力、右心室流出道梯度和环扎部位的肺动脉大小保持在血管成形术后立即获得的值。尸检表明没有肺动脉损伤的证据。尽管这些研究是初步的,但它们表明可以进行可逆性肺动脉环扎术。

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