Park Joonhong, Kim Myungshin, Lee Hae Kyung, Kim Yonggoo, Han Kyungja, Son Jungok, Lee Seok, Chung Nack-Gyun, Cho Bin
Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Int J Hematol. 2014 Mar;99(3):279-87. doi: 10.1007/s12185-014-1513-2. Epub 2014 Jan 29.
The aim of the present study was to analyze chromosome abnormalities in Korean patients with T-cell acute lymphoblastic leukemia (T-ALL). A total of 65 patients with newly diagnosed T-ALL were enrolled in the study from December 2004 to December 2011. Chromosome analysis was performed at diagnosis on short-term cultures of bone marrow specimens. Of these 65 patients, abnormal karyotypes were found in 50 (77 %). Numerical and structural chromosome abnormalities were identified in 16 (25 %) and 47 (72 %) patients, respectively. Deletion was the most common structural abnormality (48 %), followed by translocation (29 %). Overall survival (OS) and relapse-free survival (RFS) outcome were unaffected by the number and/or type of chromosome abnormalities in both childhood and adult T-ALL; however, the OS interval was longer for childhood patients than for adult patients in the entire cohort (P = 0.0003). Similarly, patients with first complete remission (CR) showed a better OS than those who failed to achieve first CR (P < 0.0001). There was a negative clinical impact in adult patients and patients without first CR according to multivariate analysis. This study helps to fill the gap regarding chromosome findings in T-ALL and may lead to identification of the molecular background behind phenotypic differences.
本研究的目的是分析韩国T细胞急性淋巴细胞白血病（T-ALL）患者的染色体异常情况。2004年12月至2011年12月，共有65例新诊断的T-ALL患者纳入本研究。在诊断时对骨髓标本的短期培养物进行染色体分析。在这65例患者中，50例（77%）发现核型异常。分别在16例（25%）和47例（72%）患者中鉴定出染色体数目和结构异常。缺失是最常见的结构异常（48%），其次是易位（29%）。在儿童和成人T-ALL中，总体生存（OS）和无复发生存（RFS）结果均不受染色体异常数量和/或类型的影响；然而，在整个队列中，儿童患者的OS间隔比成人患者更长（P = 0.0003）。同样，首次完全缓解（CR）的患者OS比未达到首次CR的患者更好（P < 0.0001）。多因素分析显示，成人患者和未达到首次CR的患者存在负面临床影响。本研究有助于填补T-ALL染色体研究结果方面的空白，并可能有助于确定表型差异背后的分子背景。
