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使用Tegress填充剂后发生尿道皮肤瘘:病例报告及文献综述

Urethrocutaneous fistula after use of Tegress bulking agent: Case report and review of the literature.

作者信息

Mukkamala Anudeep, Latini Jerilyn M, Cameron Anne P

机构信息

Department of Urology, University of Michigan Hospitals and Health Centers, Ann Arbor, MI.

出版信息

Can Urol Assoc J. 2013 Nov-Dec;7(11-12):E833-6. doi: 10.5489/cuaj.481.

DOI:10.5489/cuaj.481
PMID:24475008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3879730/
Abstract

We report a case of a 68-year-old man who presented with a urethrocutaneous fistula after off-label use of Tegress (C. R. Bard, Inc., Murray Hill, NJ) Urethral Implant for post-prostatectomy incontinence. He was treated for prostate cancer with an open radical retropubic prostatectomy and adjuvant external beam radiation therapy. He was treated unsuccessfully for stress incontinence with a Tegress Urethral Implant and presented to our clinic initially with extrusion of the material urethrally. Four years later he re-presented with a large bullous skin lesion on his suprapubic area. Contrast-enhanced magnetic resonance imaging and retrograde urethral cystogram demonstrated a urethrocutaneous fistula. Subsequent cystoscopy revealed the calcified extruded material in the same location as the site of Tegress injection. The patient underwent simple cystectomy with ileal diversion. He recovered well postoperatively. This appears to be the first reported case of urethrocutaneous fistula after use of a Tegress Urethral Implant for post-prostatectomy stress urinary incontinence.

摘要

我们报告了一例68岁男性病例,该患者在非适应证使用泰格斯(C.R.巴德公司,新泽西州默里山)尿道植入物治疗前列腺切除术后尿失禁后出现尿道皮肤瘘。他接受了开放性耻骨后根治性前列腺切除术及辅助性体外放射治疗以治疗前列腺癌。他使用泰格斯尿道植入物治疗压力性尿失禁未成功,最初因植入材料经尿道挤出而前来我们诊所就诊。四年后,他再次就诊,耻骨上区域出现一个大的水疱性皮肤病变。增强磁共振成像和逆行尿道膀胱造影显示存在尿道皮肤瘘。随后的膀胱镜检查发现钙化的挤出材料位于泰格斯注射部位相同位置。该患者接受了单纯膀胱切除术及回肠代膀胱术。术后恢复良好。这似乎是首例使用泰格斯尿道植入物治疗前列腺切除术后压力性尿失禁后出现尿道皮肤瘘的报道病例。

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本文引用的文献

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Surgical practice patterns for male urinary incontinence: analysis of case logs from certifying American urologists.男性尿失禁的手术实践模式:对认证美国泌尿科医生病例记录的分析。
J Urol. 2012 Jul;188(1):205-10. doi: 10.1016/j.juro.2012.03.012. Epub 2012 May 15.
2
Cystoscopic injections of dextranomer hyaluronic acid into proximal urethra for urethral incompetence: efficacy and adverse outcomes.经尿道近端注射透明质酸聚糖治疗尿道功能不全:疗效和不良结局。
Urology. 2010 Jun;75(6):1310-4. doi: 10.1016/j.urology.2009.12.061. Epub 2010 Mar 17.
3
Randomized controlled multisite trial of injected bulking agents for women with intrinsic sphincter deficiency: mid-urethral injection of Zuidex via the Implacer versus proximal urethral injection of Contigen cystoscopically.针对固有括约肌缺陷女性的注射填充剂随机对照多中心试验:通过Implacer装置进行尿道中段注射Zuidex与膀胱镜下近端尿道注射Contigen对比研究
Urology. 2009 Oct;74(4):771-5. doi: 10.1016/j.urology.2009.05.034. Epub 2009 Aug 5.
4
Complications of ethylene vinyl alcohol copolymer as an intraurethral bulking agent in men with stress urinary incontinence.乙烯-乙烯醇共聚物作为压力性尿失禁男性尿道内填充剂的并发症
Urology. 2008 Apr;71(4):662-5. doi: 10.1016/j.urology.2007.10.016. Epub 2008 Feb 15.
5
Long-term results and patients' satisfaction after transurethral ethylene vinyl alcohol (Tegress) injections: a two-centre study.经尿道注射乙烯乙烯醇(Tegress)后的长期疗效及患者满意度:一项双中心研究。
Int Urogynecol J Pelvic Floor Dysfunct. 2008 Apr;19(4):503-7. doi: 10.1007/s00192-007-0479-5. Epub 2007 Oct 23.
6
Ethylene vinyl alcohol copolymer erosions after use as a urethral bulking agent.作为尿道填充剂使用后乙烯-乙烯醇共聚物的侵蚀情况
Obstet Gynecol. 2007 Feb;109(2 Pt2):490-2. doi: 10.1097/01.AOG.0000252261.55000.b2.
7
The safety and efficacy of ethylene vinyl alcohol copolymer as an intra-urethral bulking agent in women with intrinsic urethral deficiency.乙烯-乙烯醇共聚物作为内在性尿道缺损女性尿道内填充剂的安全性和有效性。
Int Urogynecol J Pelvic Floor Dysfunct. 2007 Aug;18(8):869-73. doi: 10.1007/s00192-006-0251-2. Epub 2006 Nov 14.
8
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9
Giant prostatic urethral calculus associated with urethrocutaneous fistula.
Int J Urol. 2006 May;13(5):643-4. doi: 10.1111/j.1442-2042.2006.01374.x.
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