Vyas S, Bradford H F
Departement de Neurochimie, C.N.R.S., Gif sur Yvette, France.
Neurosci Lett. 1987 Nov 10;82(1):58-64. doi: 10.1016/0304-3940(87)90171-6.
The amino acid content of Torpedo synaptosomes was investigated. It was found that glutamate and taurine were particularly enriched, their concentration exceeding that of acetylcholine by 50-60%. Other amino acids such as alanine, gamma-aminobutyric acid (GABA), glycine, leucine and phenylalanine were also present, but in smaller quantities. The neurotransmitter-releasing agents gramicidin, calcium ionophore A23187, High K+ and Glycera venom all released acetylcholine, as shown previously. However, both glutamate and taurine were found to be released by these agents together with acetylcholine. The efflux of all 3 compounds was found to be largely calcium dependent.
对电鳐突触体的氨基酸含量进行了研究。结果发现，谷氨酸和牛磺酸特别丰富，它们的浓度比乙酰胆碱高出50 - 60%。其他氨基酸如丙氨酸、γ-氨基丁酸（GABA）、甘氨酸、亮氨酸和苯丙氨酸也存在，但含量较少。如先前所示，神经递质释放剂短杆菌肽、钙离子载体A23187、高钾和甘油毒液都能释放乙酰胆碱。然而，发现谷氨酸和牛磺酸也会被这些试剂与乙酰胆碱一起释放出来。发现所有这3种化合物的外流在很大程度上依赖于钙。
