Almond N M, Worms M J, Harnett W, Parkhouse R M
Division of Immunology, National Institute for Medical Research, Mill Hill, London.
Parasitology. 1987 Dec;95 ( Pt 3):559-68. doi: 10.1017/s003118200005798x.
The class-specific antibody responses of 3 strains of mice (C57/Bl10, BALB/C and CBA/N) known to vary in their ability to control the microfilaraemia which follows the subcutaneous transplantation of adult female Dipetalonema viteae has been investigated. The 3 mouse strains showed significant variation (a) in total levels of immunoglobulins and (b) in ability to recognize individual radio-isotope-labelled antigens as measured by coprecipitation. Within each mouse strain it was noted that antigens could vary with respect to the nature of the isotype of the antibody response which they elicited. Furthermore, by comparing results obtained from class-specific coprecipitation with surface ELISA it was found that a similar variation between responses to individual epitopes was also likely. No differences were observed in the humoral response of the 3 mouse strains which could explain the known resistance of the C57/Bl10 strain; reasons for this are discussed.
已知3种小鼠品系（C57/Bl10、BALB/C和CBA/N）在控制成年雌性魏氏棘唇线虫皮下移植后出现的微丝蚴血症的能力上存在差异，对其特异性抗体反应进行了研究。这3种小鼠品系在（a）免疫球蛋白总水平和（b）通过共沉淀测量识别单个放射性同位素标记抗原的能力方面表现出显著差异。在每个小鼠品系中，注意到抗原所引发的抗体反应的同种型性质可能会有所不同。此外，通过比较特异性类别共沉淀与表面ELISA的结果，发现对单个表位的反应之间也可能存在类似差异。在这3种小鼠品系的体液反应中未观察到能够解释C57/Bl10品系已知抗性的差异；对此进行了讨论。
