Guo Jia, Li Feng-ran, Liu Yang, Cheng Mao-sheng
Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, China.
Yao Xue Xue Bao. 2013 Nov;48(11):1637-43.
Carbonic anhydrase IX (CA IX) is a tumor associated protein which is able to be a potent anticancer target, since it is highly expressed in a multitude of carcinomas, while it is present in a limited number of normal tissues. This review focuses on its role in tumor physiology, the most recent three dimensional structure features of this enzyme which has recently been elucidated. In addition, we present recent advances in the development of small inhibitors able to target CA IX for therapeutic applications.
碳酸酐酶IX（CA IX）是一种肿瘤相关蛋白，由于它在多种癌症中高度表达，而在有限数量的正常组织中存在，因此它能够成为一个有效的抗癌靶点。本综述重点关注其在肿瘤生理学中的作用，以及最近阐明的该酶的三维结构特征。此外，我们还介绍了能够靶向CA IX用于治疗应用的小分子抑制剂开发的最新进展。
