血清卵泡抑素样蛋白3在随后发生先兆子痫的孕妇孕中期升高。
Serum Follistatin-like-3 was elevated in second trimester of pregnant women who subsequently developed preeclampsia.
作者信息
Han Xiujun, He Jing, Wang Aiping, Dong Minyue
机构信息
Obstetric Department, Women's Hospital, School of Medicine, Zhejiang University , Zhejiang Province , China.
出版信息
Hypertens Pregnancy. 2014 Aug;33(3):277-82. doi: 10.3109/10641955.2013.874439. Epub 2014 Jan 29.
OBJECTIVE
To determine whether serum Follistatin-like-3 was enhanced in second trimester of pregnant women who subsequently developed preeclampsia.
METHODS
Thirty-nine pregnant women subsequently developed preeclampsia and 73 normal pregnancy women were included. Serum samples taken in 24-28 weeks gestation were used for assay of Follistatin-like-3.
RESULTS
Follistatin-like-3 was significantly elevated in preeclampsia group compared with control. However, there was no significant difference of Follistatin-like-3 in women with mild or severe preeclampsia.
CONCLUSION
The elevation of Follistatin-like-3 was demonstrated in late second trimester of pregnancy destined to developing preeclampsia, suggesting its causal role in the pathogenesis and prediction of preeclampsia.
目的
确定随后发生子痫前期的孕妇在孕中期血清卵泡抑素样蛋白3是否升高。
方法
纳入39例随后发生子痫前期的孕妇和73例正常孕妇。采集妊娠24 - 28周时的血清样本用于检测卵泡抑素样蛋白3。
结果
子痫前期组卵泡抑素样蛋白3显著高于对照组。然而，轻度或重度子痫前期患者的卵泡抑素样蛋白3无显著差异。
结论
在注定发生子痫前期的妊娠中期晚期，卵泡抑素样蛋白3升高，提示其在子痫前期发病机制和预测中起因果作用。
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