Holbrook R H, Krovoza A M, Schelley S, Ferguson J E
Department of Gynecology and Obstetrics, Stanford University School of Medicine, CA 94305.
Prenat Diagn. 1987 Nov;7(9):653-5. doi: 10.1002/pd.1970070907.
Anencephaly in twin B was accompanied by elevated amniotic fluid alpha-fetoprotein (AFP) and a positive acetylcholinesterase (AChE) band on gel electrophoresis in both twin sacs, although twin A was normal. AChE results did not help distinguish the false positive AFP in this set of twins, implying that AChE may diffuse transamniotically as has been previously postulated for AFP. In light of the low concordance rate for neural tube defects in twins, patient counselling in this situation must include the information that AFP and AChE may be falsely elevated in normal twin when the other twin has a neural tube defect.
双胎妊娠中，尽管双胎A正常，但双胎B患无脑儿，伴有两个羊膜囊中羊水甲胎蛋白（AFP）升高，且凝胶电泳显示乙酰胆碱酯酶（AChE）带呈阳性。AChE结果无助于区分这组双胎中AFP的假阳性情况，这意味着AChE可能如先前推测的AFP那样经羊膜扩散。鉴于双胎中神经管缺陷的一致性率较低，这种情况下对患者的咨询必须包含如下信息：当另一个双胎患有神经管缺陷时，正常双胎的AFP和AChE可能会出现假升高。
