Tamaki Motoyuki, Fujitani Yoshio
Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine.
Nihon Eiseigaku Zasshi. 2014;69(1):15-23. doi: 10.1265/jjh.69.15.
Pancreatic β cells contain the highest amount of zinc among cells within the human body, and hence, the relationship between zinc and diabetes has been of great interest. To date, many studies of zinc and diabetes have been reported, including studies demonstrating that diabetic patients and mice have a decreased amount of zinc in the pancreas. Zinc may counteract the deleterious effects of oxidative stress, which contributes to reduced insulin resistance, and may also protect pancreatic β cells from glucolipotoxicity. Recently, we have shown that SLC30A8/zinc transporter 8, which is a transporter expressed on the surface of insulin granules, plays a key role in zinc transport into insulin granules and in the regulation of hepatic insulin clearance. Here, we review the role of zinc in whole-body maintenance and the latest information on the relationship between zinc and diabetes.
胰腺β细胞含锌量在人体细胞中是最高的，因此，锌与糖尿病之间的关系一直备受关注。迄今为止，已有许多关于锌与糖尿病的研究报道，包括一些研究表明糖尿病患者和小鼠的胰腺中锌含量降低。锌可能会抵消氧化应激的有害影响，这有助于降低胰岛素抵抗，还可能保护胰腺β细胞免受糖脂毒性。最近，我们发现溶质载体家族30成员8/锌转运体8（SLC30A8/zinc transporter 8），一种在胰岛素颗粒表面表达的转运体，在锌转运到胰岛素颗粒以及调节肝脏胰岛素清除方面起着关键作用。在此，我们综述锌在全身维持中的作用以及锌与糖尿病关系的最新信息。
