Passath A, Leb G, Warnkross H
Medizinischen Universitätsklinik Graz.
Acta Med Austriaca. 1987;14(3-4):72-4.
The iodine organification in thyroid gland was inhibited by application of Thyrostatic (Methimazole, Carbimazole) and consequently, thyroid hormone production and excretion were diminished. Carbimazole is converted to Methimazole in vivo and in vitro. Equivalent doses of Carbimazole and Methimazole are 0.6 to 1.0. Methimazole penetrates through the placenta, therefore established therapy with Methimazole (or Carbimazole) and thyroid hormone are contradicted in states of gravidity. In hyperthyroidism, preferred therapy strategy is accepted as Methimazole and/or Carbimazole only and in low doses, respectively (40-60 mg Methimazole as first step, consequently to doses down to 5-10 mg daily); accompaning rates of hematopoetic damage are dose responded.
应用抗甲状腺药（甲巯咪唑、卡比马唑）可抑制甲状腺内的碘有机化，从而减少甲状腺激素的产生和排泄。卡比马唑在体内和体外均可转化为甲巯咪唑。卡比马唑和甲巯咪唑的等效剂量为0.6至1.0。甲巯咪唑可透过胎盘，因此在妊娠状态下，甲巯咪唑（或卡比马唑）与甲状腺激素的既定治疗方法相互矛盾。在甲状腺功能亢进症中，首选治疗策略分别是仅使用低剂量的甲巯咪唑和/或卡比马唑（第一步为40 - 60毫克甲巯咪唑，随后剂量降至每日5 - 10毫克）；造血损伤的伴随发生率与剂量相关。
