Leem Juyoung, Kang Hyun Wook, Ko Seung Hwan, Sung Hyung Jin
Department of Mechanical Engineering, KAIST, Yuseong-Gu, 291 Daehak-ro, Daejeon 305-701, Korea.
Nanoscale. 2014 Mar 7;6(5):2895-901. doi: 10.1039/c3nr04829b. Epub 2014 Jan 29.
We present a microfluidic patterning system for fabricating nanostructured Ag thin films via a polyol method. The fabricated Ag thin films can be used immediately in a real-time SERS sensing system. The Ag thin films are formed on the inner surfaces of a microfluidic channel so that a Ag-patterned Si wafer and a Ag-patterned PDMS channel are produced by the fabrication. The optimum sensing region and fabrication duration for effective SERS detection were determined. As SERS active substrates, the patterned Ag thin films exhibit an enhancement factor (EF) of 4.25 × 10(10). The Ag-patterned polymer channel was attached to a glass substrate and used as a microfluidic sensing system for the real-time monitoring of biomolecule concentrations. This microfluidic patterning system provides a low-cost process for the fabrication of materials that are useful in medical and pharmaceutical detection and can be employed in mass production.
我们展示了一种微流控图案化系统，用于通过多元醇法制备纳米结构的银薄膜。所制备的银薄膜可立即用于实时表面增强拉曼光谱（SERS）传感系统。银薄膜形成于微流控通道的内表面，从而通过该制备过程得到带有银图案的硅晶片和带有银图案的聚二甲基硅氧烷（PDMS）通道。确定了有效SERS检测的最佳传感区域和制备持续时间。作为SERS活性基底，图案化的银薄膜表现出4.25×10(10)的增强因子（EF）。带有银图案的聚合物通道附着在玻璃基板上，并用作微流控传感系统，用于实时监测生物分子浓度。这种微流控图案化系统为制备在医学和药物检测中有用的材料提供了一种低成本工艺，并且可用于大规模生产。
