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作为核基质成分的磷脂:其可能的生物学意义。

Phospholipids as components of the nuclear matrix: their possible biological significance.

作者信息

Cocco L, Martelli A M, Billi A M, Cataldi A, Miscia S, Mottola M R, Manzoli L

机构信息

Institute of Citomorfologia Normale e Patologica C.N.R., Istituto Rizzoli, Bologna.

出版信息

Basic Appl Histochem. 1987;31(3):413-9.

PMID:2447871
Abstract

The phospholipid involvement in the regulation of the functional and structural properties of the nuclear matrix is discussed analysing the results obtained with the enzymic removal of these molecules. Namely phospholipids seem to mediate hydrophobic interactions between nucleic acids and matrix fibrils either directly or indirectly through an association with the non-histone proteins of the matrix.

摘要

通过分析去除这些分子的酶促反应所获得的结果,讨论了磷脂在核基质功能和结构特性调节中的作用。也就是说,磷脂似乎直接或通过与核基质的非组蛋白结合间接介导核酸与基质纤维之间的疏水相互作用。

相似文献

1
Phospholipids as components of the nuclear matrix: their possible biological significance.作为核基质成分的磷脂:其可能的生物学意义。
Basic Appl Histochem. 1987;31(3):413-9.
2
Phospholipids and nuclear RNA.磷脂与核RNA
Cell Biol Int. 1996 Jun;20(6):407-12. doi: 10.1006/cbir.1996.0051.
3
Phosphoinositide signalling in nuclei of Friend cells: DMSO-induced differentiation reduces the association of phosphatidylinositol-transfer protein with the nucleus.弗氏细胞细胞核中的磷酸肌醇信号传导:二甲基亚砜诱导的分化降低了磷脂酰肌醇转移蛋白与细胞核的结合。
Biochem Biophys Res Commun. 1997 Jan 13;230(2):302-5. doi: 10.1006/bbrc.1996.5950.
4
The intranuclear amount of phospholipase C beta 1 decreases following cell differentiation in Friend cells, whereas gamma 1 isoform is not affected.在弗瑞德细胞中,细胞分化后,磷脂酶Cβ1的核内含量减少,而γ1亚型则不受影响。
Eur J Cell Biol. 1995 Sep;68(1):25-34.
5
Phosphoinositide signaling in nuclei of Friend cells: phospholipase C beta down-regulation is related to cell differentiation.弗氏细胞细胞核中的磷酸肌醇信号传导:磷脂酶Cβ下调与细胞分化有关。
Cancer Res. 1994 May 15;54(10):2536-40.
6
Nuclear but not cytoplasmic phospholipase C beta 1 inhibits differentiation of erythroleukemia cells.细胞核而非细胞质中的磷脂酶Cβ1抑制红白血病细胞的分化。
Cancer Res. 1998 Nov 15;58(22):5057-60.
7
Distribution of globin genes and histone variants in micrococcal nuclease-generated subfractions of chromatin from Friend erythroleukemia cells at different malignant states.不同恶性状态下,来自弗氏红白血病细胞的微球菌核酸酶产生的染色质亚组分中珠蛋白基因和组蛋白变体的分布。
J Cell Biochem. 1994 Jan;54(1):110-21. doi: 10.1002/jcb.240540112.
8
Structural and functional aspects of nuclear lipids in normal and tumor cells.
Biochemistry (Mosc). 2000 May;65(5):525-45.
9
Lipid composition of Friend leukemia cells following induction of erythroid differentiation by dimethyl sulfoxide.经二甲基亚砜诱导红系分化后的弗瑞德白血病细胞的脂质组成
J Cell Physiol. 1982 Jan;110(1):50-5. doi: 10.1002/jcp.1041100109.
10
[Interaction of various nuclear matrix proteins with DNA].[多种核基质蛋白与DNA的相互作用]
Biokhimiia. 1988 Feb;53(2):256-62.

引用本文的文献

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Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production.磷酸肌醇 4-磷酸是 G 蛋白偶联受体刺激磷酸肌醇产生的主要来源。
Sci Signal. 2018 Sep 11;11(547):eaan1210. doi: 10.1126/scisignal.aan1210.
2
Phospholipids: key players in apoptosis and immune regulation.磷脂:细胞凋亡和免疫调节中的关键分子。
Molecules. 2009 Nov 30;14(12):4892-914. doi: 10.3390/molecules14124892.