Minatoguchi Shinya
Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan, Yanagido 1-1, Gifu, Gifu 501-1194, Japan.
Curr Hypertens Rev. 2013 Aug;9(3):219-23. doi: 10.2174/1573402110666140131161338.
Coronary artery spasm is one of the causes of angina pectoris,acute myocardial infarction and ventricular fibrillation-related sudden death. It has been established that Ca channel blockers are protective against vasospastic angina (VSA) and treatment with Ca channel blockers provides a better prognosis of VSA. However, it is not still clarified what kinds of Ca channel blockers shows the best prognosis of VSA. We performed a meta-analysis in which 4Ca channel blockers amlodipine, nifedipine, benidipine and diltiazem were used for the treatment of VSA patients and found that among 4 Ca channel blockers, benidipine showed a statistically significant better prognostic effect on MACE than amlodipine, nifedipine or diltiazem.
冠状动脉痉挛是心绞痛、急性心肌梗死及与心室颤动相关的猝死的病因之一。已证实钙通道阻滞剂对血管痉挛性心绞痛（VSA）具有保护作用，且使用钙通道阻滞剂治疗可使VSA的预后更佳。然而，何种钙通道阻滞剂对VSA显示出最佳预后仍未明确。我们进行了一项荟萃分析，其中使用氨氯地平、硝苯地平、贝尼地平及地尔硫䓬这4种钙通道阻滞剂治疗VSA患者，结果发现，在这4种钙通道阻滞剂中，贝尼地平对主要不良心血管事件（MACE）的预后效果在统计学上显著优于氨氯地平、硝苯地平或地尔硫䓬。
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