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[肝性脑病的预防]

[Prevention of hepatic encephalopathy].

作者信息

Morillas Rosa M, Sala Marga, Planas Ramon

机构信息

Unidad de Hepatología, Servicio de Aparato Digestivo, Hospital Germans Trias i Pujol, Badalona, Barcelona, España; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, España.

Unidad de Hepatología, Servicio de Aparato Digestivo, Hospital Germans Trias i Pujol, Badalona, Barcelona, España; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, España.

出版信息

Med Clin (Barc). 2014 Jun 6;142(11):512-4. doi: 10.1016/j.medcli.2013.11.027. Epub 2014 Jan 28.

Abstract

Hepatic encephalopathy (HE) is a frequent complication of cirrhosis which, in addition to producing a great social impact, deteriorates the quality of life of patients and is considered a sign of advanced liver disease and therefore a clinical indication for liver transplant evaluation. Patients who have had episodes of HE have a high risk of recurrence. Thus, after the HE episode resolves, it is recommended: control and prevention of precipitating factors (gastrointestinal bleeding, spontaneous bacterial peritonitis, use of diuretics with caution, avoid nervous system depressant medications), continued administration of non-absorbable disaccharides such as lactulose or lactitol, few or non-absorbable antibiotics such as rifaximin and assess the need for a liver transplant as the presence of a HE episode carries a poor prognosis in cirrhosis.

摘要

肝性脑病(HE)是肝硬化常见的并发症,除了产生巨大的社会影响外,还会使患者的生活质量下降,被视为晚期肝病的标志,因此也是肝移植评估的临床指征。发生过HE发作的患者复发风险很高。因此,在HE发作缓解后,建议如下:控制和预防诱发因素(消化道出血、自发性细菌性腹膜炎、谨慎使用利尿剂、避免使用神经系统抑制药物),持续给予不可吸收的双糖,如乳果糖或乳糖醇,少量或给予不可吸收的抗生素,如利福昔明,并评估肝移植的必要性,因为HE发作在肝硬化中预后较差。

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