胸腺激素THF对感染小鼠巨细胞病毒（MCMV）的小鼠免疫反应的恢复作用。
Restoration of immunological responses by THF, a thymic hormone, in mice infected with murine cytomegalovirus (MCMV).
作者信息
Katorza E, Pecht M, Apte R N, Benharroch D, Burstein Y, Trainin N, Rager-Zisman B
机构信息
Department of Microbiology and Immunology, Ben Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
Clin Exp Immunol. 1987 Nov;70(2):268-75.
Cytomegalovirus causes T cell immune impairment in infected mice, reflected by a decreased response to the T cell mitogens PHA and Con A, and reduction of Con A-induced IL-2 secretion. Concomitantly, a marked increase in the spleen weight of infected mice was found. Histological examination of the liver revealed focal hepatitis. These signs of infection lasted from day 5 to day 14 after infection when mice slowly started to recover. Systemic treatment of MCMV-infected mice with thymic humoral factor (THF) resulted in a reconstitution of the mitogenic responses, IL-2 secretion, normalization of spleen weight and recovery of liver inflammation. Unlike other thymic hormones, THF did not affect interferon synthesis and NK cytotoxicity in infected mice. It is concluded that THF restores immune competence of mice immunosuppressed as a result of MCMV infection, through modulation of the T cell compartment.
巨细胞病毒会导致受感染小鼠的T细胞免疫功能受损，这表现为对T细胞促有丝分裂原PHA和Con A的反应降低，以及Con A诱导的白细胞介素-2分泌减少。与此同时，发现受感染小鼠的脾脏重量显著增加。肝脏的组织学检查显示有局灶性肝炎。这些感染迹象在感染后第5天至第14天持续存在，之后小鼠开始缓慢恢复。用胸腺体液因子（THF）对感染巨细胞病毒的小鼠进行全身治疗，可使有丝分裂反应、白细胞介素-2分泌得到重建，脾脏重量恢复正常，肝脏炎症也得以恢复。与其他胸腺激素不同，THF不会影响受感染小鼠的干扰素合成和自然杀伤细胞的细胞毒性。结论是，THF通过调节T细胞区室，恢复了因巨细胞病毒感染而免疫抑制的小鼠的免疫能力。
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