脂肪量与肥胖相关（FTO）基因和抗精神病药物所致体重增加：一项关联研究。
Fat mass- and obesity-associated (FTO) gene and antipsychotic-induced weight gain: an association study.
作者信息
Shing Emily C, Tiwari Arun K, Brandl Eva J, Zai Clement C, Lieberman Jeffrey A, Meltzer Herbert Y, Kennedy James L, Müller Daniel J
机构信息
Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ont., Canada.
出版信息
Neuropsychobiology. 2014;69(1):59-63. doi: 10.1159/000356231. Epub 2014 Jan 30.
OBJECTIVES
Genetic variation in the fat mass- and obesity-associated gene (FTO) has been associated with obesity in the general population. In this study we have investigated these variants for association with antipsychotic-induced weight gain (AIWG).
METHODS
A total of 218 patients with chronic schizophrenia or schizoaffective disorder treated mostly with clozapine or olanzapine for up to 14 weeks were included in the study. We analyzed 4 polymorphisms in intron 1 of the FTO gene (rs1421085, rs8050136, rs9939609, rs9930506) for association with AIWG using ANCOVA.
RESULTS
No statistically significant associations were observed between the single nucleotide polymorphisms and AIWG. However, patients homozygous for the A-allele of rs9939609 gained numerically higher weight than the other genotypic groups (AA: 5.26 ± 6.7%; TA: 4.66 ± 5.6%; TT: 4.21 ± 5.3%).
CONCLUSION
Our current observations suggest that the FTO gene variants investigated may not play a major role in AIWG.
目的
脂肪量和肥胖相关基因（FTO）的遗传变异与普通人群的肥胖有关。在本研究中，我们调查了这些变异与抗精神病药物所致体重增加（AIWG）的相关性。
方法
本研究共纳入218例慢性精神分裂症或分裂情感性障碍患者，这些患者主要接受氯氮平或奥氮平治疗长达14周。我们使用协方差分析（ANCOVA）分析了FTO基因内含子1中的4个多态性（rs1421085、rs8050136、rs9939609、rs9930506）与AIWG的相关性。
结果
未观察到单核苷酸多态性与AIWG之间存在统计学显著相关性。然而，rs9939609的A等位基因纯合患者的体重增加数值高于其他基因型组（AA：5.26±6.7%；TA：4.66±5.6%；TT：4.21±5.3%）。
结论
我们目前的观察结果表明，所研究的FTO基因变异可能在AIWG中不发挥主要作用。
Zotero 插件