Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, 410078, China.
Neurosci Bull. 2019 Jun;35(3):561-580. doi: 10.1007/s12264-018-0323-6. Epub 2019 Jan 3.
Antipsychotic-induced weight gain (AIWG) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. We aimed to review the progress of pharmacogenetic studies on AIWG in the Chinese population to compare the results for Chinese with other ethnic populations, identify the limitations and problems of current studies, and provide future research directions in China. Both English and Chinese electronic databases were searched to identify eligible studies. We determined that > 25 single-nucleotide polymorphisms in 19 genes have been investigated in association with AIWG in Chinese patients over the past few decades. HTR2C rs3813929 is the most frequently studied single-nucleotide polymorphism, and it seems to be the most strongly associated with AIWG in the Chinese population. However, many genes that have been reported to be associated with AIWG in other ethnic populations have not been included in Chinese studies. To explain the pharmacogenetic reasons for AIWG in the Chinese population, genome-wide association studies and multiple-center, standard, unified, and large samples are needed.
抗精神病药引起的体重增加（AIWG）是这种治疗的常见不良反应，特别是第二代抗精神病药，它是全世界的一个主要健康问题。我们旨在综述中国人群中抗精神病药引起的体重增加的遗传药理学研究进展，将中国人群的结果与其他种族人群进行比较，确定当前研究的局限性和问题，并为中国未来的研究提供方向。我们检索了中英文电子数据库以确定符合条件的研究。在过去几十年中，我们确定了 19 个基因中的 >25 个单核苷酸多态性与中国患者的 AIWG 相关。HTR2C rs3813929 是研究最多的单核苷酸多态性，它似乎与中国人群的 AIWG 相关性最强。然而，许多在其他种族人群中被报道与 AIWG 相关的基因并未包含在中国的研究中。为了解释中国人群中 AIWG 的遗传药理学原因，需要进行全基因组关联研究和多中心、标准、统一和大样本研究。
