Bernasconi Maurizio, Ramella Vincenzo, Tosatti Paolo, Pfaltz Andreas
Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056, Basel (Switzerland), Fax: (+41) 61-267-1103.
Chemistry. 2014 Feb 24;20(9):2440-4. doi: 10.1002/chem.201303915. Epub 2014 Jan 30.
Ir-phosphinomethyl-oxazoline complexes have been identified as efficient, highly enantioselective catalysts for the asymmetric hydrogenation of 3,3-disubstituted allylic alcohols and related homoallylic alcohols. In contrast to other N,P ligand complexes, which require weakly coordinating solvents, such as dichloromethane, these catalysts perform well in more ecofriendly THF or 2-MeTHF. Their synthetic potential was demonstrated with the formal total synthesis of four bisabolane sesquiterpenes.
