[采用共振血栓成像技术检测急性白血病中的因子 XIII 缺乏症]

[Detection of factor XIII deficiency in acute leukemia with resonance thrombography].

作者信息

Anders O, Görss E W, Ernst B, Konrad H

机构信息

Klinik für Innere Medizin, Bereiches Medizin, Wilhelm-Pieck-Universität Rostock.

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(5):670-9.

PMID:2448208

Abstract

In 16 patients affected with acute leukemia (7 patients with acute lymphatic leukemia and 9 patients with acute myeloid leukemia) the resonance thrombogramme was recorded during cytostatic induction therapy, coagulation factor XIII (subunit XIII-A, XIII-S) and further hemostasiological parameters were determined. Subunit XIII-A was lowered to 36%, subunit XIII-S to 65% and the fibrin formation time of the resonance thrombogramme was extended to 9 minutes. There exists a negative correlation between component XIII-A and fibrin formation time r = -0.48 (p less than 0.01). The influence exerted by diminishing factor XIII and fibrin(ogen) splitting products on the fibrin formation time was investigated in in-vitro tests. A diminution of factor XIII below 10% will extend the fibrin formation time to about 10 minutes, an increase of fibrin(ogen) splitting products to 100 micrograms/ml to about 3 minutes.

摘要

在16例急性白血病患者（7例急性淋巴细胞白血病和9例急性髓细胞白血病）中，在细胞毒性诱导治疗期间记录共振血栓图，测定凝血因子 XIII（亚基 XIII-A、XIII-S）及其他止血参数。亚基 XIII-A 降至36%，亚基 XIII-S 降至65%，共振血栓图的纤维蛋白形成时间延长至9分钟。亚基 XIII-A 与纤维蛋白形成时间之间存在负相关，r = -0.48（p < 0.01）。在体外试验中研究了凝血因子 XIII 减少和纤维蛋白（原）降解产物对纤维蛋白形成时间的影响。凝血因子 XIII 减少至10%以下会使纤维蛋白形成时间延长至约10分钟，纤维蛋白（原）降解产物增加至100微克/毫升会使纤维蛋白形成时间延长至约3分钟。