Mahto Sunita, Sharma S B, Dwivedi S, Puri D, Tripathi R L
Department of Biochemistry, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-110095.
Coronary Care Unit, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-110095
J Assoc Physicians India. 2013 May;61(5):317-9.
In women with coronary artery disease (CAD), clinical presentation is different enough from men which leads to missed or delayed diagnosis. Biomarkers can be used for assessment of CAD patients. In case control study, we analyzed blood samples of 30 controls, 30 cases of Unstable Angina (UA) and 30 cases of Myocardial Infarction (MI) for Pro-inflammatory markers (hs-CRP, IL-6, ICAM-1) and Pregnancy Associated Plasma Protein-A (PAPP-A). Based on discriminant analysis, hs-CRP is the potential marker to discriminate cases of UA from controls while PAPP-A is the reliable marker which can discriminate the cases of MI from UA and controls.
在患有冠状动脉疾病（CAD）的女性中，临床表现与男性有足够的差异，这导致诊断遗漏或延迟。生物标志物可用于评估CAD患者。在病例对照研究中，我们分析了30名对照者、30例不稳定型心绞痛（UA）患者和30例心肌梗死（MI）患者的血液样本，检测促炎标志物（hs-CRP、IL-6、ICAM-1）和妊娠相关血浆蛋白-A（PAPP-A）。基于判别分析，hs-CRP是区分UA患者与对照者的潜在标志物，而PAPP-A是能够区分MI患者与UA患者及对照者的可靠标志物。
