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Hypoxia-inducible factor-1α in pulmonary arterial smooth muscle cells and hypoxia-induced pulmonary hypertension.

作者信息

Smith Kimberly A, Yuan Jason X-J

机构信息

1 Department of Medicine University of Illinois at Chicago Chicago, Illinois.

出版信息

Am J Respir Crit Care Med. 2014 Feb 1;189(3):245-6. doi: 10.1164/rccm.201312-2148ED.

Abstract
摘要

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Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α.
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2
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Unfavourable consequences of chronic cardiac HIF-1α stabilization.
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Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1α-mediated TRPC signalling.
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Conditional HIF-1alpha expression produces a reversible cardiomyopathy.
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Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.
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TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling.
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