Indications of the existence of ferroelectric units in excitable-membrane channels.

Previous work in excitability has focused primarily on the mathematical description of the phenomena, while mechanisms postulated to explain these were simple mechanical interpretations of the terms of this description. The problem considered here is that of the physical mechanism underlying excitation. The experimental facts to be explained must be not only the electrical behavior of the membrane, but also its electromechanical, electro-optic and thermoelectric behavior. Previous work on the physically grounded electrodiffusion theory foundered not because of the incorrectness of the electrodiffusion approach, but because the assumed description of the dielectric properties of the membrane was too simple. Extension of the dielectric equation of state to a nonlinear polynomial form converts the classical electrodiffusion system of equations into a nonlinear polynomial form converts the classical electrodiffusion system of equations into a ferroelectric electrodiffusion system. The consideration of ferroelectric behavior in excitable channels makes possible straight-forward physical explanation of the phenomena of membrane swelling during action potential, currents induced by temperature changes, transition temperatures, current-voltage hysteresis, nonlinear electrical behavior, voltage-dependent birefringence and rectangular pulses from single channels. The hypothesis is therefore proposed that excitable channels contain ferroelectric transmembrane units. These may be crystals or liquid crystals.