London E, Fanelli R, Szikszay M, Jasinski D
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
NIDA Res Monogr. 1986;75:379-81.
The autoradiographic 2-deoxy-D-[1-14C]glucose ([14-C]DG) method was used to map the effects of morphine, oxymorphone and nalbuphine on local cerebral glucose utilization (LCGU), an index of local brain function. The mu agonists (morphine, oxymorphone) decreased LCGU in thalamic nuclei, including some which have been implicated in somatosensory processing. Nalbuphine did not produce these effects, but stimulated LCGU in nuclei of the spinal trigeminal tract. The findings suggest that different supraspinal mechanisms mediate the actions of mu vs. kappa opioids, and that the [14-C]DG procedure is helpful in elucidating the anatomical areas involved.
采用放射自显影2-脱氧-D-[1-14C]葡萄糖（[14-C]DG）法来描绘吗啡、羟吗啡酮和纳布啡对局部脑葡萄糖利用（LCGU）的影响，LCGU是局部脑功能的一个指标。μ激动剂（吗啡、羟吗啡酮）降低了丘脑核团中的LCGU，其中一些核团与躯体感觉处理有关。纳布啡未产生这些效应，但刺激了脊髓三叉神经束核团中的LCGU。这些发现表明，不同的脊髓上机制介导了μ与κ阿片类药物的作用，且[14-C]DG程序有助于阐明所涉及的解剖区域。
